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However, it is not clear whether dosing reductions would be necessary in elderly patients, since these pharmacokinetic alterations may be offset by age-related differences in responsiveness of target organs and/or less pronounced suppression of adrenal release of cortisol

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doi: 10.1111/j.1742-4658.2008.06542.x 29 MasipL.VeeravalliK.GeorgiouG

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Methylene blue is not suitable for those with G6PD deficiency or those on contraindicated medications