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Nature 380:435439 Henry TD, Annex BH, McKendall GR, Azrin MA, Lopez JJ, Giordano FJ, Shah PK, Willerson JT, Benza RL, Berman DS et al (2003) The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis

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Recommendations for future research Future research studies should prioritise adequately powered, multicentre, double-blind RCTs of NAC in PD with rigorous controls, standardised dosing regimens, clearly defined routes of administration, and stratification by disease stage and baseline oxidative stress markers to identify patient subgroups most likely to benefit