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Thus, the inhibitory activities are only directed against microbial proteases and not against granule proteinases, suggesting that they may act as endogenous antibiotics [90]

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Critically, this technique 'offered a powerful tool for studying the triggering events at the initiation of the immune system' (Andersson, Sjberg, Obel)

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Studies demonstrate FOXO4-DRI achieves comparable renal function restoration to genetic clearance of senescent cells using the p16-3MR suicide gene system, confirming that therapeutic effects result specifically from senescent cell elimination rather than off-target actions