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Randomization occurred after a 6-week run-in period consisting of a 3-week initial forced metformin titration period followed by a maintenance period of another 3 weeks

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Additionally, electrophysiological experiments have shown the direct effects of B vitamins on pain transmission pathways in the spinal cord and thalamus, which explains the observed reduction or loss of pain sensation in clinical patients

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IL-1 and cyclooxygenase-2 (COX-2) play a detrimental role in adipose tissue dysfunction in obesity [76]