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(2012) 7:e50300

In the SURMOUT-1 trial 2,539 patients underwent randomization to tirzepatide or placebo and were followed for 72 weeks demonstrating up to 20.9% weight reduction with maintenance dosing versus 3.1% in the placebo group for a net 17.8% weight reduction [35]

Unfortunately, patients may not be aware that taking isotretinoin with a high-fat meal is necessary for optimal absorption and efficacy, or they may be unwilling to regularly adhere to taking isotretinoin with such a high intake of dietary fat with each dose