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The majority (90%) of the APAP is funneled into phase II metabolic pathways, in which APAP conjugation is catalyzed by UDP-glucuronosyl transferases (UGT) and sulfotransferase (SULT), with conversion to glucouronidated and sulfated metabolites that are eliminated from the body in the urine8 (Figure 1)

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If sleep disturbance persists beyond 8 weeks of GLP-1 therapy, or if melatonin use does not improve sleep quality within 2-3 weeks, contact your prescribing provider

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