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Whilst pharmacological combinations remain clinically unsupported for retatrutide at this stage, there is robust evidence that certain lifestyle interventions can meaningfully complement weight-loss pharmacotherapy

Both Wegovy and Ozempic are associated with a reduced risk of cardiovascular disease

For this reason, we recommend starting Isotretinoin (Accutane ) at a lower dose for the first month, and gradually increasing therapy to minimize any significant flaring

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