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Psychiatry 66 , e99 (2023)

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Naltrexone, approved in 1984, introduced a non-opioid antagonist that blocked the effects of opioids but required full detoxification before initiation, limiting its early use

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Clinical data beyond 26 weeks is limited, but observational evidence suggests diminishing returns after week 20-24 as VAT reduction plateaus and the body reaches a new homeostatic setpoint