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In patients with type 2 diabetes, sitagliptin (100 mg/day) therapy significantly reduced the plasma levels of C-reactive protein (CRP), IL-6, IL-18, secreted phospholipase-A2, soluble intracellular adhesion molecule- (ICAM-) 1, and E-selectin compared with placebo

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The two models we have used in this study are different in that one involves global germ line deletion of the D 2 R while the other involves a 7-day renal subcapsular infusion of Drd2 siRNA in the remaining kidney of uninephrectomized mice that decreases renal D 2 R expression by 6070%