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In acute ischemic stroke, TrkB mediates pro-survival signaling while p75NTR mediates pro-apoptotic signaling, and the therapeutic strategy involves activating TrkB signaling and inhibiting p75NTR signaling (Alnoaman et al., 2025)

This is why the BPC-157 + TB-500 combination outperforms double-dosing either compound alone

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Moreover, subcutaneous administration of NiH could also achieve the above effects, not only in lymph nodes, but also in peripheral blood (71)