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Ther Clin Risk Manag (2007) 3(1):13348

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Using a degraded or contaminated solution carries real clinical risks, including injection site reactions, systemic infection, or unpredictable pharmacological effects

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Caution should be used when hydrochlorothiazide is administered to patients with gout or hyperuricemia since thiazide diuretics have been reported to reduce the clearance of uric acid