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Oxidation and reduction of actin: origin, impact in vitro and functional consequences in vivo

Proc Natl Acad Sci U S A 94: 28692873

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Slowing the dose escalation schedule, temporarily returning to a lower dose, or holding at the current dose longer than recommended are options that can improve tolerability while still achieving therapeutic benefits

With the progressive decline in the use of DPP-4 inhibitors [22, 23], the phenotype of patients initiating oral semaglutide may change accordingly

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