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Annals Of Internal Medicine 2024, 177: 1499-1508

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545 For example, pelacarsen, an Lp(a) ASO drug developed by Ionis in collaboration with Novartis AG, effectively lowers Lp(a) levels by selectively cleaving Apo(a) gene (LPA) mRNA

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4,5 Despite these advantages, concerns about potential adverse effects, including gastrointestinal intolerance and possible cardiovascular adaptations that may influence bone health, warrant further investigation

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