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Adverse events, such as hypoglycemia, cancer, pancreatitis, and heart failure were similar with alogliptin and placebo ( The Sitagliptin CVOT In the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) study, 14,671 patients with type 2 diabetes and established cardiovascular disease were randomized to addition of sitagliptin or placebo to existing therapy for a median follow-up period of 3.0 years