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however, the GSH antioxidant system can be overwhelmed if ROS are produced in excess, leading to increased levels of free radicals that can damage molecules that are essential to cellular homeostasis and metabolism

Gut Health Glutathione is also seen in boosting gut health by protecting the gut lining, lowering inflammation, and helping maintain tight junctions

As far as I know, the increase above that dose isn't associated with a better result, so i think above 500mg is maybe overkill

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Rosenthal, P

B12 isn't a fast-acting anxiolytic it's a slow rebuild of the biochemical infrastructure that supports emotional regulation