Further research is needed to determine the efficacy of the L-carnitine supplementation among older adults with different frailty status, that is, frail, for a longer intervention period, different doses, and also combined with exercise
For example, a GWAS study in European populations identified that the 15q25.1 locus variation in the CHRNA5 gene (such as rs55781567) significantly increases lung cancer risk, but only in individuals who have smoked previously
The effects and potential toxicity of other forms remain untested
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