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Abstract Background The prevalence of obesity has been increasing worldwide, with substantial implications for public health

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Given that TMCA can promote the GLP-1 production as a natural FXR antagonist 30 , we speculated that TMCA is a major contributor to the T3 effect on GLP-1 and insulin production and glucose homeostasis

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However, not every patient experiences maximal weight loss, and individual responses depend on factors like starting weight, lifestyle, and genetic predisposition

Advanced imaging techniques, such as 3D multiplex imaging 149 , enable spatially resolved analysis of EEC-microbiome interactions, shedding light on how these cells communicate within their native environment