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Long-term drug desensitization may cause Y2 receptor down-regulation or signal desensitization, thus weakening its long-term efficacy

The samples were then incubated at room temperature for 1 h while shaking at 1,000 rpm

Before anyone throws their pen in the bin, read the caveats, because they change the meaning

Lipohypertrophy represents another potential cause, particularly in patients who repeatedly inject into the same site