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In the current setting of the COVID-19 pandemic, good glycemic control (along with control of other risk factors) has been shown to reduce morbidity and mortality in patients with T2DM [8]

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In addition, the potential of hydrochlorothiazide to indirectly impair the function of pyruvate carboxylase by inhibiting carbonic anhydrase Vb (Kucharczyk et al., 2023) may have widespread physiological implications

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