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Compelling evidence for direct PRR activation is derived from studies on B cells, which express multiple TLRs

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However, no single classification captures the extent of AML clinical heterogeneity 12 , underscoring the need for tumor classification beyond established genetic features

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3,73 Additionally, lipoxygenases (LOXs) are a family of iron-containing enzymes that directly oxidize PUFAs in cell membranes and PUFA-containing lipids, mediating lipid peroxidation to produce hydrogen peroxide