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TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis

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10.1038/srep26064 484 WangL.YangZ.HeX.PuS.YangC.WuQ.et al (2022)

Comprehensive Anti-Inflammatory Effects The research reveals GLP-1 receptor agonists provide anti-inflammatory benefits throughout the body: Cardiovascular Protection : GLP-1 receptor agonists reduce inflammation and oxidative stress in coronary artery disease, decrease arterial stiffness, and reduce myocardial fibrosiskey factors in cardiovascular protection

The expression of the VD metabolism genes CYP2R1 and CYP27A1 (25-hydroxylase), CYP27B1 (1--hydroxylase), and vitamin D receptor (VDR) were downregulated in the livers of mice fed an HFD (GSH- deficient) compared with control diet-fed group