The rationale is mechanistic (complementary pathways with no known antagonism) and supported by clinical experience from physicians who prescribe both
The patient pool already exists
Ashley SN, Nordin JML, Buza EL, Greig JA, Wilson JM (2018) Adeno-associated viral gene therapy corrects a mouse model of argininosuccinic aciduria
Because GH and IGF-1 promote protein synthesis and lipolysis, these hormonal changes provide a plausible mechanistic basis for modest increases in lean body mass, improved recovery and support for fat loss seen in clinical and observational contexts, but robust controlled trials explicitly measuring those endpoints are still lacking
Does the color of my semaglutide affect how well it works
This potential effect on inflammation has led some scientists to wonder if semaglutide might help people with inflammatory diseases such as RA