doi: 10.1146/annurev.pharmtox.43.100901.140229
It represents a fundamentally different approach from the three compounds ranked above
6-OHDA, a hydroxylated analogue of dopamine, is widely recognized for its ability to induce severe oxidative stress and dopaminergic neuronal damage both in vitro and in vivo, making it a commonly used agent for PD model induction (Masoudi et al
They also compared the catalytic rate of GSH reduction induced by single-atom Pd nanozyme, Cu 2-x Te nanozyme, and copper hexacyanoferrate nanozyme (SSNEs) (Figure 1D), ( FIGURE 1 The transition of metal ions valence would also be a powerful strategy for GSH exhaustion
Additionally, vitamin C regenerates other antioxidants including vitamin E, amplifying the bodys overall antioxidant defence
[177] Austin DW, Spolding B, Gondalia S, Shandley K, Palombo EA, Knowles S, Walder K