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Pregnancy, breastfeeding, kidney disease, severe anemia, and neurologic symptoms may require closer follow-up

This cost differential has enormous implications for treatment duration

Some studies report a reduction in alcohol and nicotine intake, whereas results for opioids and stimulant use disorders are less conclusive

Matsuda and coworkers [45] demonstrated a considerable reduction in serum free carnitine concentration in five patients with hyperammonaemia associated with VPA therapy (of whom three had a Reye-like syndrome)

Use of GLP-1RAs for other conditions One thing is for sure, despite this class of medications being primarily sold for diabetes and now for weight loss, they are being investigated for much more beyond their potential use for MCAS

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