Lysyl oxidase requires copper as a cofactor for its catalytic activity, and copper availability is a regulatory point in extracellular matrix biology
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two published tirzepatide case series (Naranjo "probable"), FAERS reporting odds ratio 22.55 for allodynia across GLP-1 with tirzepatides neuro-AE proportion lower than semaglutides, class cohort signal (aHR 2.15) in related agents