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Conclusion: MR analysis showed a possible causal relationship between the genetically predicted concentration of Cu and the risk of GD, whereas the genetically predicted concentrations of Ir, Zn, Ca, VC, and VD may not be causally related to the risk of GD

On the other hand, RWE lacks the ability to establish causality by minimising confounding effects which is a key strength of randomised clinical trials (RCTs)

It is noteworthy that the incidence of aortic valve malformations is higher in males compared with females, and that this phenomenon is also seen in older and younger individuals

DPP-4i=dipeptidyl peptidase-4 inhibitor

5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD

Abnormal neural progenitor cells differentiated from induced pluripotent stem cells partially mimicked development of TSC2 neurological abnormalities