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Overall, the depletion of GSH in Individuals with HIV emerges as a critical factor disrupting redox homeostasis, jeopardizing the intricate coordination of immune cell activities, and contributing to immune dysfunction, rendering them more susceptible to secondary infections, particularly Mycobacterium tuberculosis (TB) [34,35]

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Though, applications of antifolate or inhibitors targeting methionine biosynthesis were shown to cause restrained infections of P