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10.1016/j.yjmcc.2013.12.015 J Mol Cell Cardiol

Nrf2 displays both pro- and anti-atherogenic effects in experimental animal models, and the Nrf2 pathway becomes a promising target for atherosclerosis prevention (234)

as a result my skin got super tanned and my body color do not have equal color

The reduction of KEAP1 and phosphoglycerate mutase family member 5 demonstrated that the KEAP1-phosphoglycerate mutase family member 5-apoptosis-inducing factor mitochondrion-associated 1 signalling pathway is responsible for the death of melanocytes initiated by oxidative stress [6]

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Its a swish done orally to absorb sublingually/submucousaly