clinical trial semaglutide Reduces Heavy Drinking in Obesity and Alcohol Use Disorder | Professor Erwin Loh posted on the topic Weekly semaglutide improves blood sugar

This is the same mechanism that makes people feel full after small meals, and it is partly why some people report still feeling hungry on tirzepatide at lower doses where gastric emptying is less affected

Bandholtz, S., Wichard, J., Khne, R

Many users will need long-term or indefinite treatment to maintain liver improvements

I mean, not everyone is going to want to inject something weekly for weight loss

During week one at a low starting dose, GLP-1 receptors begin responding to the new agonist

It may also trigger adaptive metabolic responses that slow weight loss over time and increase the likelihood of weight regain after treatment cessation