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In contrast, adult-onset deletion of the Keap1 gene exclusively in renal tubular cells caused no abnormalities in renal structure or function [67], demonstrating that overactivation of Nrf2 in the mature renal epithelium makes kidneys resistant to oxidative injuries without any significant abnormalities

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Although peptides have been used systemically for decades, their application in orthopaedicsparticularly for tendon healing, cartilage repair, and muscle recoveryhas only recently gained attention