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A lot more people ought to check this out and understand this side of the story

doi:10.1002/jor.22831 Pickart L, Vasquez-Soltero JM, Margolina A

These mechanisms are investigated in cell-culture and animal models, not in humans

In contrast, GLP-1 RAs such as tirzepatide had ICERs approaching $197,000 per QALY in some models [8], well beyond typical WTP thresholds used in health policy evaluations