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In their announcement about the retatrutide study, Eli Lilly medical experts said that about 11% of study volunteers who received the highest dose of the drug stopped taking it and dropped out of the study due to unpleasant side effects

1 Long-term evidence from SURPASS-4 The SURPASS-4 trial followed participants for up to 104 weeks (2 years), providing reassurance about longer-term use

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Sustained GIPR agonism shifts post-prandial glucose toward glycerol production and promotes lipolysis during fasting, enhancing lipid clearance and mobilization beyond what GLP-1R agonism achieves alone 14

The approval process accelerated due to the impressive results of clinical trials showing significant weight loss in patients and adults with obesity and without diabetes

Over-the-Counter Remedies : Some patients find relief using OTC anti-nausea medications like meclizine or Dramamine