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Phase Maximum dose Weeks 17-20+ Weekly Dose 12 mg Notes Highest dose studied

130,138 As a negative regulator, CDH8 participates in the canonical Wnt signalling pathway by directly binding to -catenin or being recruited to the promoter regions of -catenin-responsive genes

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Patients using tirzepatide show reductions in blood pressure (average 46 mmHg systolic), improved lipid profiles with lower triglycerides, and reduced insulin resistanceall independent of weight loss