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Traditionally GLP-1(9-36) was considered inactive, however more recent studies indicate that GLP-1(9-36) can contribute to inhibiting glucagon secretion by inhibiting voltage-gated calcium channels through a GPCR mechanism, an effect which reduces the number of glucagon containing vesicles that are available for exocytosis, thereby contributing the the decrease in glucagon secretion (Figure 1)(Zheng et al, 2024)

Discontinuation rates due to adverse events are 4.3-7.1% for tirzepatide versus 24.6% for survodutide

Taurine attenuates hepatic steatosis in a genetic model of fatty liver disease

Saxenda (liraglutide) was a prescription-only medication licensed for weight management

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