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Secondly, sleep plays a crucial role in regulating the activity of the hypothalamicpituitaryadrenal (HPA) axis

The PKC pathway becomes activated through hyperglycemia-induced increases in diacylglycerol (DAG), with PKC- and PKC- isoforms particularly implicated in stimulating NOX activity while inhibiting AMPK-mediated antioxidant responses (Geraldes and King, 2018)

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Traditional treatment approaches focus primarily on reducing stomach acid production through proton pump inhibitors or H2 blockers