If it continues, GERD can cause scarring and narrowing of the esophagus and increase a persons risk of esophageal cancer.Results show that people taking GLP-1 drugs were 27% more likely to develop GERD and 55% more likely to have GERD complications, when compared to people taking SGLT-2 inhibitors.More than 90% of GERD complications involved Barrett esophagus, in which acid damage changes the tissue lining of the esophagus and increases cancer risk, researchers noted.We also found that the risk for GERD was higher with long-acting GLP-1 (drug) use, researchers wrote.However, they noted that these findings need to be verified by studies involving other groups, including those taking GLP-1 drugs for obesity.There is limited evidence on the risk for GERD among patients with obesity who do not have type 2 diabetes, researchers wrote
It is commonly believed to be safe for periods of use
on the other hand, enhancing -arrestin-2 action by the overexpression of G protein receptor kinase 5 (GRK5) increases GLP-1R endocytosis 35
It has also been found that meningococcal IgA protease can translocate to the nucleus of the host cell because of the presence of a nuclear localization signal
However, N-acetylcysteine (NAC), a glutathione precursor, has the strongest clinical evidence and is used in NHS hospitals, making it a more reliable option despite not being a direct glutathione supplement
Gou H, Zeng R, Lau HCH, Yu J
