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They primarily function by reducing iron levels and inhibiting oxidative stress to prevent cell death (109111)

Estos medicamentos estn contraindicados en pacientes con antecedentes personales o familiares de carcinoma medular de tiroides o sndrome de neoplasia endocrina mltiple tipo 2 (MEN2), y deben usarse con precaucin en pacientes con antecedentes de pancreatitis, enfermedad vesicular o gastroparesia severa

The triggers of activating self-reactive clones are still to be determined, but may be common infections, molecular mimicry, or inflammation signals from gut microbiota (Westall, 2006)

This rise in deaths due to overdose was driven by increased lethal overdose of nearly all drug classes studied (including opioids, benzodiazepines, and stimulants)