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they are specialized within the cytosol, endoplasmic reticulum, mitochondria, and lysosome, each with distinct folding environments, surveillance machinery, and stress-response programs (Fig

Although RCC4 VHL/ cells demonstrated lower glutathione levels compared with those of RCC4 VHL (+/+) cells, this observation was consistent with the analyses of other cancer cell lines

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van Heel, M

Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)