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Most commercial products (including Hospira 30 mL vials, the standard used in research) carry a 23 year expiration from manufacture
Although it cannot yet be determined whether vitamin B 12 deficiency plays a causal role in depression, it may be beneficial to screen for vitamin B 12 deficiency in older individuals as part of a medical evaluation for depression
B12 is found in animal-based sources such as meat, fish, poultry, eggs, and dairy products
Chemically, vitamin B12 can exist in various forms, but all of them contain the mineral cobalt
In mice at thermoneutrality, repeated dosing increases energy expenditure, lowers RER, reduces fat mass and adipocyte size, and improves hepatic lipid metrics