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Cutting or crushing the tablet would: Disrupt the specialized coating and formulation designed for gastric absorption Potentially alter the pharmacokinetic profile, leading to unpredictable drug levels Reduce bioavailability, as oral semaglutide already has low absorption (approximately 1% bioavailability per FDA labeling) Create inconsistent dosing between the two halves Expose the patient to medication that may not be absorbed effectively The American Diabetes Association guidelines emphasize that medications should be taken as prescribed and formulated unless specifically indicated otherwise by the manufacturer

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[13] In each trial, HbA1c was measured from the start of the trial to the end of the trial and compared between the semaglutide group and the other groups