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Lancet infect
doi: 10.1021/acs.accounts.0c00014, 2
GSH brain concentrations are not commonly measured using 1 H-MRS, because relative to other 1 H-MRS-detectable neurochemicals (e.g., creatine (Cr), choline, N -acetylasparate), GSH concentrations are substantially lower
For example, using peptides together with medicines metabolized by cytochrome P450 can lead to increased levels of these medicines in the blood, which may raise the risk of side effects
4 In addition, SLC25A39 expression in adult dopaminergic neurons of the midbrain could be demonstrated by the same authors
The stringent quality standards and specific formulations required in pharmaceuticals necessitate substances of proven efficacy and safety, aligning with glutathione's well-documented role in cellular defense mechanisms
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