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Both medications share comparable safety profiles, with common gastrointestinal side effects including nausea, vomiting, diarrhea, and abdominal pain that are generally mild to moderate and resolve as the body adjusts

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Furthermore, the various orientations of both the substrates and UCEs in the modeled structures suggest that the different UCEs may have preferences to transfer ubiquitin to one type of substrate (e.g., neosubstrate) over another (e.g., native)