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With this aside in mind, we can focus our discussion on the patients treated for a longer duration of time

Its pharmacological actions on glucose metabolism involve the LKB1-AMPK pathway, which appears to activate ataxia-telangiectasia mutants and activation-induced cytidine deaminase (ATM) [20]

The resulting weight lossoften 15-20% of body weight with higher doses approved for obesity (Wegovy/Zepbound) and 5-10% with lower doses for diabetes (Ozempic/Mounjaro)can actually improve several cardiovascular risk factors

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