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The phase 3 REDEFINE program, published in The New England Journal of Medicine and presented at the American Diabetes Associations Scientific Sessions in June 2025, put the combination to the test

PMID: 16490817, DOI: 10.1161/circulationaha.105.591446

Glutathione is a powerful antioxidant that can help protect your cells from damage and improve your immune systems function

For both supplements: Allergies to NAD+ or L-GLutathione Specific contraindications for NAD+: Children / anyone under 18 years old Those with active or historic cancer People who are pregnant or breastfeeding Those with lyme disease Those who have recently had a skin graft Those with atrial fibrillation Anyone who is classed as immunosuppressed Those who have had an organ transplant Those with a history of haemophilus influenza bacteria Specific contraindications for L-Glutathione+: Those with allergies to Glutathione Those who are pregnant or breastfeeding Those using blood thinners or anti-coagulants Those using chemotherapy agents (Cisplatin, Doxorubicin, etc) Those with asthma Those with unknown health issues

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The CJC-1295 in the PeRx combo is the no-DAC version (Modified GRF 1-29), so both peptides are short-acting and pulsatile