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In contrast, DPP-4 inhibitors exert a natriuretic effect by acting primarily on distal segments, apparently by enhancing the effects of SDF-1 [99] (Fig

Furthermore, GLP-1 has been shown to stimulate calcitonin secretion from the thyroid gland, which may further contribute to protective effects on bone, 25 but whether this action is relevant in humans still needs to be clarified

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Practical Strategies to Minimize Nausea on GLP-1 Therapy Starting at the lowest effective dose and gradually increasing it over 4-8 weeks substantially reduces nausea intensity compared to faster dose escalation