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In the UK, typical oral doses for dietary deficiency are 50-150 micrograms daily, with higher doses (1000-2000 micrograms) generally reserved for clinical situations under healthcare supervision

References McKenna HT, Murray AJ, Martin DS

High non-ceruloplasmin-bound copper can increase oxidative stress, while low zinc may impair copper regulation and SOD1/SOD3 structure

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Recent advances in nanotechnology have yielded multifunctional platforms incorporating GSH-responsive linkages, redox-active metals, and prodrug designs with strong promise for targeted delivery and theranostics

Quantitative Real-Time PCR A total RNA extraction kit (Vazyme, Nanjing, China) was used to collect total RNA from TPC-1 and KTC-1 cells