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Whether sorafenib induces ferroptosis in RCC cells and the identity of its target need to be further explored [284]

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While a temporary decrease in NCOA4 results in less breakdown of ferritin, leading to increased iron storage and therefore less available iron in the cell [41], long-term reduction in NCOA4 expression or function, as observed in animal studies, leads to an overload of iron and oxidative stress [42]