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Under physiological conditions, the Neh2 structural domain of Nrf2 binds to Kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm, facilitating Nrf2 ubiquitination and subsequent degradation ( 3.1.3 TRPM4 channels and endothelial dysfunction in atherosclerosis Ye et al

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As food digestion and nutrient absorption take place in the Small Intestine, bacteria in this section of the intestine can cause malabsorption, excessive gas, bloating, and abdominal discomfort as they eat the nutrients