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Herein we show, in vivo and ex vivo, in murine and human models, that CB1R plays a key role in the initiation of insulitis and that its pharmacological blockade can ameliorate this pathophysiological process

holding at the starting dose is a deliberate request, and not every doctor will agree

It may be relevant to oxidative and acidbase stress, but it should not be described as directly removing creatinine or reversing kidney failure without stronger evidence

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An abdominal CT scan can also help understand the cause of kidney enlargement if observed on ultrasound