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4b) suggests that the metabolic response is mounted quickly but sustained and enhanced over time, given that ~75% of the metabolic DEGs at 24 h are also found at 48 h (Extended Data Fig

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Shared Decision-Making : Treatment decisions should involve the adolescent, their family, and a multidisciplinary healthcare team

National Center for Complementary and Integrative Health notes that randomized, placebo-controlled trials are the gold standard because they help determine whether apparent improvement is due to the treatment or to chance

Similar to other antidiabetic medications, such as metformin [40], and in combination with diet and exercise, the reduction in insulin resistance induced by GLP-1 RAs may help reduce or resolve AN